The child completed chemotherapy successfully, and is currently disease-free. The chemotherapy regimen in group G had strong killing ability on tumor with neuroblastoma cell rate of 0%, and negative expression of CD56, CGA, SYN, which was recommended as the optimal regimen. The chemotherapy regimens in group B and D showed toxicity with the larger decrease of weight in mice. Results: The PDX mouse model was successfully established with the same pathologic characteristics as the child's neuroblastoma. The feasibility and effectiveness of the individualized therapy were also verified in another 3 patients. After individualized therapy, the therapeutic effect was evaluated by glioblastoma specific indicators and imaging examination. The physical condition, weight of mice, the pathological changes and protein expressions were observed to select the best clinical treatment. The mice were divided into different groups treated with different anti-tumor drugs for 1 week. Methods: The tumor tissues from a child with neuroblastoma were transplanted into NSG mice to establish neuroblastoma PDX. Purpose: To establish a neuroblastoma patient derived xenograft (PDX) mouse model to select antitumor drug and guide individualized therapy.
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